Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer
Joint Authors
Kang, Dan
Zuo, Wenren
Wu, Qingxin
Zhu, Qingyi
Liu, Ping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Phloretin is a flavonoid existed in various plants and has been reported to possess anticarcinogenic activity.
However, the anticancer mechanism of phloretin in prostate cancer (PCa) remains unclear.
Here, our in vitro and in vivo experimental data demonstrate that phloretin inhibits the phosphorylation and the activation of EGFR and then inhibits its downstream PI3K/AKT and MEK/ERK1/2 pathways in PCa cells.
Inhibition of these two pathways further decreases expression of Sp1 by inhibiting Sp1 gene transcription, induces degradation of Sp1 protein by inhibiting GSK3β phosphorylation, suppresses nucleolin-enhanced translation of Sp1 mRNA by inhibiting nucleolin phosphorylation, and directly inactivates transcription activity of Sp1.
Inhibition of Sp1 subsequently decreases the expression of Sp3/4, VEGF, and Survivin and then upregulates apoptosis-related proteins and downregulates cell cycle-related proteins in PCa cells.
Finally, phloretin treatment in PCa cells induces cell growth inhibition and apoptosis, suggesting that phloretin may be an effective therapy compound in the treatment of prostate cancer.
American Psychological Association (APA)
Kang, Dan& Zuo, Wenren& Wu, Qingxin& Zhu, Qingyi& Liu, Ping. 2020. Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1131588
Modern Language Association (MLA)
Kang, Dan…[et al.]. Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1131588
American Medical Association (AMA)
Kang, Dan& Zuo, Wenren& Wu, Qingxin& Zhu, Qingyi& Liu, Ping. Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1131588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131588