Metabolic Volumetric Parameters in 11C-Choline PETMR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer
Joint Authors
Hong, Ji-Hong
Tseng, Jing-Ren
Yang, Lan-Yan
Liu, Chung-Yi
Pang, See-Tong
Lin, Yu-Chun
Yen, Tzu-Chen
Wang, Li-Jen
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Positron emission tomography/magnetic resonance imaging (PET/MRI) can facilitate the use of noninvasive imaging biomarkers in clinical prostate cancer staging.
Although multiparametric MRI is a widely used technique, the clinical value of simultaneous PET imaging remains unclear.
This study aimed at investigating this issue.
Methods.
Between January 2015 and December 2016, 31 high-risk prostate cancer patients underwent 11C-choline PET/MRI for staging purposes.
Clinical characteristics and imaging parameters, including the standardized uptake value (SUV) and metabolic volumetric parameters from PET imaging; apparent diffusion coefficient (ADC) values from diffusion-weighted imaging; and volume transfer rate constant (Ktrans), reflux rate constant (Kep), and initial area under curve (iAUC) in 60 seconds from dynamic contrast-enhanced (DCE) MRI were analyzed.
Results.
11C-Choline PET imaging parameters were significantly correlated with prostate-specific antigen (PSA) levels, and metabolic volumetric parameters, including metabolic tumor volume (MTV) and uptake volume product (UVP), showed significant correlations with other MRI parameters.
In our cohort analysis, the PET/MRI parameters UVP/minimal ADC value (ADCmin) and kurtosis of Kep (Kepkur)/ADCmin were significant predictors for progression-free survival (PFS) (HR = 1.01, 95% CI: 1.00–1.02, p=0.031 and HR = 1.09, 95% CI: 1.02–1.16, p=0.009, respectively) in multivariate Cox regression analysis.
High UVP/ADCmin and Kepkur/ADCmin values were significantly associated with shorter PFS.
Conclusions.
Metabolic volumetric parameters such as MTV and UVP can be routinely used as PET imaging biomarkers to add prognostic value and show better correlations in combination with MR imaging parameters in high-risk prostate cancer patients undergoing 11C-choline PET/MRI.
American Psychological Association (APA)
Tseng, Jing-Ren& Yang, Lan-Yan& Lin, Yu-Chun& Liu, Chung-Yi& Pang, See-Tong& Hong, Ji-Hong…[et al.]. 2018. Metabolic Volumetric Parameters in 11C-Choline PETMR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131619
Modern Language Association (MLA)
Tseng, Jing-Ren…[et al.]. Metabolic Volumetric Parameters in 11C-Choline PETMR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131619
American Medical Association (AMA)
Tseng, Jing-Ren& Yang, Lan-Yan& Lin, Yu-Chun& Liu, Chung-Yi& Pang, See-Tong& Hong, Ji-Hong…[et al.]. Metabolic Volumetric Parameters in 11C-Choline PETMR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131619