Noninferiority of 99mTc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to 18F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer
Joint Authors
Dai, Dong
Rollo, F. David
Bryant, Jerry
Kim, E. Edmund
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
99 m Tc-ethylenedicysteine-glucosamine ( 99 m Tc-EC-G) was developed as a potential alternative to 18F-FDG for cancer imaging.
A Phase 2 study was conducted to compare 18F-FDG PET/CT and 99 m Tc-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCLC).
This study was aimed to demonstrate that 99 m Tc-EC-G SPECT/CT was not inferior to 18F-FDG PET/CT in patients with confirmed NSCLC.
Methods.
Seventeen patients with biopsy proven NSCLC were imaged with 99 m Tc-EC-G and 18F-FDG to detect and stage their cancers.
Imaging with PET/CT began 45–60 minutes after injection of 18F-FDG.
Imaging with 99 m Tc-EC-G began at two hours after injection (for 5 patients) or three hours (for 12 patients).
SPECT/CT imaging devices from the three major vendors of SPECT/CT systems were used at 6 participating study sites.
The image sets were blinded to all clinical information and interpreted by independent PET and SPECT expert readers at a central independent core laboratory.
Results.
100% concordance between 99 m Tc-EC-G and 18F-FDG for primary lesion detection, lesion location and size, and confidence that the biopsied lesion was malignant.
There was 70% agreement between 99 m Tc-EC-G and 18F-FDG for metastatic lesion detection, location and size, and confidence that the suspicious lesions were malignant.
Conclusions.
Evaluation of primary and suspicious metastatic lesions detected by 99 m Tc-EC-G and 18F-FDG on 17 patients resulted in excellent agreement for detection of primary and metastatic lesions.
The study results indicated that 99 m Tc-EC-G SPECT/CT has the potential to be a clinically viable alternative to 18F-FDG PET/CT and 99 m Tc-EC-G is not inferior to 18F-FDG PET/CT.
American Psychological Association (APA)
Dai, Dong& Rollo, F. David& Bryant, Jerry& Kim, E. Edmund. 2018. Noninferiority of 99mTc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to 18F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131628
Modern Language Association (MLA)
Dai, Dong…[et al.]. Noninferiority of 99mTc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to 18F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131628
American Medical Association (AMA)
Dai, Dong& Rollo, F. David& Bryant, Jerry& Kim, E. Edmund. Noninferiority of 99mTc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to 18F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131628