Standardized Uptake Values Derived from 18F-FDG PET May Predict Lung Cancer Microvessel Density and Expression of KI 67, VEGF, and HIF-1α but Not Expression of Cyclin D1, PCNA, EGFR, PD L1, and p53
Joint Authors
Meyer, Hans Jonas
Surov, Alexey
Wienke, Andreas
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Our purpose was to provide data regarding relationships between 18F-FDG PET and histopathological parameters in lung cancer.
Methods.
MEDLINE library was screened for associations between PET parameters and histopathological features in lung cancer up to December 2017.
Only papers containing correlation coefficients between PET parameters and histopathological findings were acquired for the analysis.
Overall, 40 publications were identified.
Results.
Associations between SUV and KI 67 were reported in 23 studies (1362 patients).
The pooled correlation coefficient was 0.44.
In 2 studies (180 patients), relationships between SUV and expression of cyclin D1 were analyzed (pooled correlation coefficient = 0.05).
Correlation between SUV and HIF-1α was investigated in 3 studies (288 patients), and the pooled correlation coefficient was 0.42.
In 5 studies (310 patients), associations between SUV and MVD were investigated (pooled correlation coefficient = 0.54).
In 6 studies (305 patients), relationships between SUV and p53 were analyzed (pooled correlation coefficient = 0.30).
In 6 studies (415 patients), associations between SUV and VEGF expression were investigated (pooled correlation coefficient = 0.44).
In 5 studies (202 patients), associations between SUV and PCNA were investigated (pooled correlation coefficient = 0.32).
In 3 studies (718 patients), associations between SUV and expression of PD L1 were analyzed (pooled correlation coefficient = 0.36).
Finally, in 5 studies (409 patients), associations between SUV and EGFR were investigated (pooled correlation coefficient = 0.38).
Conclusion.
SUV may predict microvessel density and expression of VEGF, KI 67, and HIF-1α in lung cancer.
American Psychological Association (APA)
Surov, Alexey& Meyer, Hans Jonas& Wienke, Andreas. 2018. Standardized Uptake Values Derived from 18F-FDG PET May Predict Lung Cancer Microvessel Density and Expression of KI 67, VEGF, and HIF-1α but Not Expression of Cyclin D1, PCNA, EGFR, PD L1, and p53. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131656
Modern Language Association (MLA)
Surov, Alexey…[et al.]. Standardized Uptake Values Derived from 18F-FDG PET May Predict Lung Cancer Microvessel Density and Expression of KI 67, VEGF, and HIF-1α but Not Expression of Cyclin D1, PCNA, EGFR, PD L1, and p53. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131656
American Medical Association (AMA)
Surov, Alexey& Meyer, Hans Jonas& Wienke, Andreas. Standardized Uptake Values Derived from 18F-FDG PET May Predict Lung Cancer Microvessel Density and Expression of KI 67, VEGF, and HIF-1α but Not Expression of Cyclin D1, PCNA, EGFR, PD L1, and p53. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131656