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Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd
Joint Authors
Yang, Xin
Chai, Wei
Ma, Xibo
Jin, Yushen
Wang, Yi
Zhang, Shuai
Peng, Dong
Li, Xuejun
Tian, Jie
Wei, Shoushui
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy.
The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence.
A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells.
In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N,N′,N,N′-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy.
For subcutaneous tumor, multimodality molecular imaging including photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) and the related processing techniques were used to monitor the pharmacokinetics process of GO-AuNS-DOTA-Gd in order to determine the optimal time for treatment.
For orthotopic tumor, MRI was used to delineate the tumor location and margin in vivo before treatment.
Then handheld photoacoustic imaging system was used to determine the tumor location during the surgery and guided the photothermal therapy.
The experiment result based on orthotopic tumor demonstrated that this synergistic method could effectively reduce tumor residual and satellite metastases by 85.71% compared with the routine photothermal method without handheld PAI guidance.
These results indicate that this multimodality molecular imaging-guided photothermal therapy method is promising with a good prospect in clinical application.
American Psychological Association (APA)
Ma, Xibo& Jin, Yushen& Wang, Yi& Zhang, Shuai& Peng, Dong& Yang, Xin…[et al.]. 2018. Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1131659
Modern Language Association (MLA)
Ma, Xibo…[et al.]. Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1131659
American Medical Association (AMA)
Ma, Xibo& Jin, Yushen& Wang, Yi& Zhang, Shuai& Peng, Dong& Yang, Xin…[et al.]. Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1131659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131659