[18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiosurgery by PETCT
Joint Authors
Qu, Bao-Lin
Yu, Xinguang
Ju, Zhongjian
Sun, Lu
Zhou, Kedi
Wang, Weijun
Zhang, Xiaojun
Zhang, Zhizhong
Wang, Jinyuan
Ling, Zhipei
Zhang, Jinming
Pan, Longsheng
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
[18F]ML-10 is a novel apoptosis radiotracer for positron emission tomography (PET).
We assess the apoptosis response of intracranial tumor early after CyberKnife (CK) treatment by [18F]ML-10 PET imaging.
29 human subjects (30 lesions), diagnosed with intracranial tumors, underwent CK treatment at 14–24 Gy in 1–3 fractions, had [18F]ML-10 positron emission tomography/computed tomography (PET/CT) before (pre-CK) and 48 hours after (post-CK) CK treatment.
Magnetic resonance imaging (MRI) scans were taken before and 8 weeks after CK treatment.
Voxel-based analysis was used for the imaging analysis.
Heterogeneous changes of apoptosis in tumors before and after treatment were observed on voxel-based analysis of PET images.
A positive correlation was observed between the change in radioactivity (X) and subsequent tumor volume (Y) (r=0.862, p<0.05), with a regression equation of Y=1.018∗X−0.016.
Malignant tumors tend to be more sensitive to CK treatment, but the treatment outcome is not affected by pre-CK apoptotic status of tumor cells; [18F]ML-10 PET imaging could be taken as an assessment 48 h after CK treatment.
American Psychological Association (APA)
Sun, Lu& Zhou, Kedi& Wang, Weijun& Zhang, Xiaojun& Ju, Zhongjian& Qu, Bao-Lin…[et al.]. 2018. [18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiosurgery by PETCT. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131662
Modern Language Association (MLA)
Sun, Lu…[et al.]. [18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiosurgery by PETCT. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131662
American Medical Association (AMA)
Sun, Lu& Zhou, Kedi& Wang, Weijun& Zhang, Xiaojun& Ju, Zhongjian& Qu, Bao-Lin…[et al.]. [18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiosurgery by PETCT. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131662