Host Genetic and Environmental Factors Shape the Composition and Function of Gut Microbiota in Populations Living at High Altitude
Joint Authors
Zhou, Youlian
Li, Kang
Peng, Wei
Ren, Yi
Zhao, Jianhua
Fu, Xiangsheng
Nie, Yuqiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The human gut microbiota is affected by genetic and environmental factors.
It remains unclear how host genetic and environmental factors affect the composition and function of gut microbiota in populations living at high altitudes.
We used a metagenome-wide analysis to investigate the gut microbiota composition in 15 native Tibetans and 12 Hans living on the Tibetan Plateau.
The composition of gut microbiota differed significantly between these two groups (P<0.05).
The Planctomycetes was the most abundant phyla both in native Tibetans and in Hans.
Furthermore, the most relatively abundant phyla for native Tibetans were Bacteroidetes (15.66%), Firmicutes (11.10%), Proteobacteria (1.32%), Actinobacteria (1.10%), and Tenericutes (0.35%), while the most relatively abundant phyla for Hans were Bacteroidetes (16.28%), Firmicutes (8.41%), Proteobacteria (2.93%), Actinobacteria (0.49%), and Cyanobacteria (0.21%).
The abundance of the majority of genera was significantly higher in Tibetans than in Hans (P<0.01).
The number of microbial genes was 4.9 times higher in Tibetans than in Hans.
The metabolic pathways and clusters of orthologous groups differed significantly between the two populations (P<0.05).
The abundance of carbohydrate-active enzyme modules and antibiotic resistance genes was significantly lower in Tibetans compared to Hans (P<0.05).
Our results suggest that different genetic factors (race) and environmental factors (diets and consumption of antibiotics) may play important roles in shaping the composition and function of gut microbiota in populations living at high altitudes.
American Psychological Association (APA)
Li, Kang& Peng, Wei& Zhou, Youlian& Ren, Yi& Zhao, Jianhua& Fu, Xiangsheng…[et al.]. 2020. Host Genetic and Environmental Factors Shape the Composition and Function of Gut Microbiota in Populations Living at High Altitude. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131678
Modern Language Association (MLA)
Li, Kang…[et al.]. Host Genetic and Environmental Factors Shape the Composition and Function of Gut Microbiota in Populations Living at High Altitude. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1131678
American Medical Association (AMA)
Li, Kang& Peng, Wei& Zhou, Youlian& Ren, Yi& Zhao, Jianhua& Fu, Xiangsheng…[et al.]. Host Genetic and Environmental Factors Shape the Composition and Function of Gut Microbiota in Populations Living at High Altitude. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131678