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A Comparative 68Ga-Citrate and 68Ga-Chloride PETCT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia
Joint Authors
Frantzén, Janek
Roivainen, Anne
Lankinen, Petteri
Noponen, Tommi
Autio, Anu
Luoto, Pauliina
Löyttyniemi, Eliisa
Hakanen, Antti J.
Aro, Hannu T.
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There may be some differences in the in vivo behavior of 68Ga-chloride and 68Ga-citrate leading to different accumulation profiles.
This study compared 68Ga-citrate and 68Ga-chloride PET/CT imaging under standardized experimental models.
Methods.
Diffuse Staphylococcus aureus tibial osteomyelitis and uncomplicated bone healing rat models were used (n=32).
Two weeks after surgery, PET/CT imaging was performed on consecutive days using 68Ga-citrate or 68Ga-chloride, and tissue accumulation was confirmed by ex vivo analysis.
In addition, peripheral quantitative computed tomography and conventional radiography were performed.
Osteomyelitis was verified by microbiological analysis and specimens were also processed for histomorphometry.
Results.
In PET/CT imaging, the SUVmax of 68Ga-chloride and 68Ga-citrate in the osteomyelitic tibias (3.6 ± 1.4 and 4.7 ± 1.5, resp.) were significantly higher (P=0.0019 and P=0.0020, resp.) than in the uncomplicated bone healing (2.7 ± 0.44 and 2.5 ± 0.49, resp.).
In osteomyelitic tibias, the SUVmax of 68Ga-citrate was significantly higher than the uptake of 68Ga-chloride (P=0.0017).
In animals with uncomplicated bone healing, no difference in the SUVmax of 68Ga-chloride or 68Ga-citrate was seen in the operated tibias.
Conclusions.
This study further corroborates the use of 68Ga-citrate for PET imaging of osteomyelitis.
American Psychological Association (APA)
Lankinen, Petteri& Noponen, Tommi& Autio, Anu& Luoto, Pauliina& Frantzén, Janek& Löyttyniemi, Eliisa…[et al.]. 2018. A Comparative 68Ga-Citrate and 68Ga-Chloride PETCT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131689
Modern Language Association (MLA)
Lankinen, Petteri…[et al.]. A Comparative 68Ga-Citrate and 68Ga-Chloride PETCT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131689
American Medical Association (AMA)
Lankinen, Petteri& Noponen, Tommi& Autio, Anu& Luoto, Pauliina& Frantzén, Janek& Löyttyniemi, Eliisa…[et al.]. A Comparative 68Ga-Citrate and 68Ga-Chloride PETCT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131689