A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma
Joint Authors
Wang, Jukun
Zhang, Chao
Li, Ang
Cao, Feng
Liu, Dongbin
Li, Fei
Luo, Tao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Increasing research attention has focused on tumor-infiltrating immune cells.
However, the threshold of an immune score for use in predicting overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) is not defined.
This study aims at exploring the association between immune scores with prognosis and building a clinical nomogram for predicting the survival of HCC patients.
Material and Methods.
A total of 299 patients were enrolled in this study.
Their clinical pathological characteristics and immune scores downloaded from The Cancer Genome Atlas (TCGA) database were analyzed.
Survival differences between different immune score subgroups were compared, and a final nomogram was built using the Cox proportional hazards regression model.
The predictive performance of the nomogram was assessed using the concordance index (C-index) and a calibration plot.
Results.
All the patients were divided into three subgroups based on immune scores.
Patients with medium and high immune scores had significantly better OS (HR and 95% CI: 0.417 [0.186-0.937] and 0.299 [0.146-0.616]) and DFS (HR and 95% CI: 0.575 [0.329-1.004] and 0.451 [0.278-0.733], respectively, compared with those with low immune scores.
The C indices for OS and DFS were 0.748 (95% CI, 0.687-0.809) and 0.675 (95% CI, 0.630-0.720), respectively.
A calibration plot used to determine the probability of survival at 3 or 5 years (OS and DFS) showed a significant agreement between nomogram predictions and actual observations.
Conclusions.
Medium and high immune scores are significantly associated with prolonged OS and DFS in HCC patients.
Nomograms built in this study can help doctors and patients assess prognosis and guide treatment.
American Psychological Association (APA)
Wang, Jukun& Zhang, Chao& Li, Ang& Cao, Feng& Liu, Dongbin& Li, Fei…[et al.]. 2020. A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131710
Modern Language Association (MLA)
Wang, Jukun…[et al.]. A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1131710
American Medical Association (AMA)
Wang, Jukun& Zhang, Chao& Li, Ang& Cao, Feng& Liu, Dongbin& Li, Fei…[et al.]. A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131710