Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3KmTORGSK3β Pathway in Neuroblastoma SH-SY5Y Cells
Joint Authors
Li, Rui
Liu, Wenzhou
Ou, Li
Gao, Feng
Li, Min
Wang, Liping
Wei, Peifeng
Miao, Feng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Emodin is an active monomer extracted from rhubarb root, which has many biological functions, including anti-inflammation, antioxidation, anticancer, and neuroprotection.
However, the protective effect of emodin on nerve injury needs to be further elucidated.
The purpose of this study is to investigate the effect of emodin on the neuroprotection and the special molecular mechanism.
Here, the protective activity of emodin inhibiting H2O2-induced apoptosis and neuroinflammation as well as its molecular mechanisms was examined using human neuroblastoma cells (SH-SY5Y cells).
The results showed that emodin significantly enhanced cell viability, reduced cell apoptosis and LDH release.
Simultaneously, emodin downregulated H2O2-induced inflammatory factors, including IL-6, NO, and TNF-α, and alleviated H2O2-induced oxidative stress and mitochondrial dysfunction in SH-SY5Y cells.
In addition, emodin inhibited the activation of the PI3K/mTOR/GSK3β signaling pathway.
What is more, the PI3K/mTOR/GSK3β pathway participated in the protective mechanism of emodin on H2O2-induced cell damage.
Collectively, it suggests that emodin alleviates H2O2-induced apoptosis and neuroinflammation potentially by regulating the PI3K/mTOR/GSK3β signaling pathway.
American Psychological Association (APA)
Li, Rui& Liu, Wenzhou& Ou, Li& Gao, Feng& Li, Min& Wang, Liping…[et al.]. 2020. Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3KmTORGSK3β Pathway in Neuroblastoma SH-SY5Y Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1131711
Modern Language Association (MLA)
Li, Rui…[et al.]. Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3KmTORGSK3β Pathway in Neuroblastoma SH-SY5Y Cells. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1131711
American Medical Association (AMA)
Li, Rui& Liu, Wenzhou& Ou, Li& Gao, Feng& Li, Min& Wang, Liping…[et al.]. Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3KmTORGSK3β Pathway in Neuroblastoma SH-SY5Y Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1131711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131711