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Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population
Joint Authors
Liu, Chuan
Yang, Jie
Huang, Lan
Shen, Yang
Zhang, Jihang
Bian, Shizhu
Zhang, Chen
Yu, Jie
Gao, Xubin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
High-altitude headache (HAH) is the most common complication after high-altitude exposure.
Hypoxia-inducible factor- (HIF-) related genes have been confirmed to contribute to high-altitude acclimatization.
We aim to investigate a possible association between HIF-related genes and HAH in the Chinese Han population.
Methods.
In total, 580 healthy Chinese Han volunteers were recruited in Chengdu (500 m) and carried to Lhasa (3700 m) by plane in 2 hours.
HAH scores and basic physiological parameters were collected within 18–24 hours after the arrival.
Thirty-five single nucleotide polymorphisms (SNPs) in HIF-related genes were genotyped, and linkage disequilibrium (LD) was evaluated by Haploview software.
The functions of SNPs/haplotypes for HAH were developed by using logistic regression analysis.
Results.
In comparison with wild types, the rs4953354 “G” allele (P=0.013), rs6756667 “A” allele (P=0.036) in EPAS1, and rs6520015 “C” allele in PPARA (P=0.009) were significantly associated with decreased risk of HAH.
The rs7292407-rs6520015 haplotype “C-C” in PPARA was identified as a protective factor (P=0.030).
Importantly, EPAS1 and PPARA genes have synergistic effects in decreasing HAH risk (P=0.003).
Conclusions.
EPAS1 and PPARA polymorphisms were associated with HAH in the Chinese Han population.
Our findings pointed out potentially predictive gene markers, provided new insights into understanding pathogenesis, and may further provide prophylaxis and treatment strategies for HAH.
American Psychological Association (APA)
Shen, Yang& Zhang, Jihang& Yang, Jie& Liu, Chuan& Bian, Shizhu& Zhang, Chen…[et al.]. 2020. Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131752
Modern Language Association (MLA)
Shen, Yang…[et al.]. Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1131752
American Medical Association (AMA)
Shen, Yang& Zhang, Jihang& Yang, Jie& Liu, Chuan& Bian, Shizhu& Zhang, Chen…[et al.]. Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131752