Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALBc Mice
Joint Authors
Guo, Li-Peng
Liu, Si-Xu
Yang, Qin
Liu, Hong-Yang
Xu, Lu-Lu
Hao, Yu-Hua
Zhang, Xiao-Qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern.
Thymoquinone (TQ) is one of the most active ingredients in Nigella sativa seeds.
It has a variety of beneficial properties including anti-inflammatory and antioxidative activities.
Here, we investigated the possible protective effects of TQ against kidney damage in septic BALB/c mice.
Eight-week-old male BALB/c mice were divided into four groups: control, TQ, cecal ligation and puncture (CLP), and TQ+CLP.
CLP was performed after 2 weeks of TQ gavage.
After 48 h, we measured the histopathological alterations in the kidney tissue and the serum levels of creatinine (CRE) and blood urea nitrogen (BUN).
We also evaluated pyroptosis (NLRP3, caspase-1), apoptosis (caspase-3, caspase-8), proinflammatory (TNF-α, IL-1β, and IL-6)-related protein and gene expression levels.
Our results demonstrated that TQ inhibited CLP-induced increased serum CRE and BUN levels.
It also significantly inhibited the high levels of NLRP3, caspase-1, caspase-3, caspase-8, TNF-α, IL-1β, and IL-6 induced by CLP.
Furthermore, NF-κB protein level was significantly decreased in the TQ+CLP group than in the CLP group.
Together, our results indicate that TQ may be a potential therapeutic agent for sepsis-induced AKI.
American Psychological Association (APA)
Guo, Li-Peng& Liu, Si-Xu& Yang, Qin& Liu, Hong-Yang& Xu, Lu-Lu& Hao, Yu-Hua…[et al.]. 2020. Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALBc Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1131753
Modern Language Association (MLA)
Guo, Li-Peng…[et al.]. Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALBc Mice. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1131753
American Medical Association (AMA)
Guo, Li-Peng& Liu, Si-Xu& Yang, Qin& Liu, Hong-Yang& Xu, Lu-Lu& Hao, Yu-Hua…[et al.]. Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALBc Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1131753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131753