Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools
Joint Authors
Mazalovska, Milena
Kouokam, J. Calvin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cancer remains a global health challenge, with high morbidity and mortality, despite the recent advances in diagnosis and treatment.
Multiple compounds assessed as novel potential anticancer drugs derive from natural sources, including microorganisms, plants, and animals.
Lectins, a group of highly diverse proteins of nonimmune origin with carbohydrate-binding abilities, have been detected in virtually all kingdoms of life.
These proteins can interact with free and/or cell surface oligosaccharides and might differentially bind cancer cells, since malignant transformation is tightly associated with altered cell surface glycans.
Therefore, lectins could represent a valuable tool for cancer diagnosis and be developed as anticancer therapeutics.
Indeed, several plant lectins exert cytotoxic effects mainly by inducing apoptotic and autophagic pathways in malignant cells.
This review summarizes the current knowledge regarding the basis for the use of lectins in cancer diagnosis and therapy, providing a few examples of plant-derived carbohydrate-binding proteins with demonstrated antitumor effects.
American Psychological Association (APA)
Mazalovska, Milena& Kouokam, J. Calvin. 2020. Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1131776
Modern Language Association (MLA)
Mazalovska, Milena& Kouokam, J. Calvin. Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1131776
American Medical Association (AMA)
Mazalovska, Milena& Kouokam, J. Calvin. Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1131776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131776