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The LncRNA H19 rs217727 Polymorphism Is Associated with Oral Squamous Cell Carcinoma Susceptibility in Iranian Population
Joint Authors
Ghapanchi, Janan
Ranjbar, Zahra
Mokhtari, Mohammad Javad
Koohpeima, Fatemeh
Derakhshan, Maryam
Khademi, Bijan
Sheikhbahaei, Shamsoddinali
Aliabadi, Ehsan
Ghaderi, Hamid
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Lack of protein-coding capacity is a main characteristic of long noncoding RNAs (lncRNAs) which, as molecular biomarkers, have found a novel pharmacological application in cancer and are reported to be important regulators of gene expression.
H19 is reportedly involved in cancer progression and tumorigenesis.
One of the most common types of head and neck cancers is oral squamous cell carcinoma (OSCC).
The main objective of the present study was to evaluate the correlation of OSCC susceptibility with H19 gene in an Iranian population.
This research was performed on 400 subjects of both sexes referred to the Namazi Hospital affiliated with the Shiraz University of Medical Sciences (SUMS).
Individuals aged 15-88 years were divided into two groups: pathologically diagnosed patients with new-onset OSCC and healthy controls.
After written and informed consent was obtained from the individuals, genomic DNA was extracted.
The tetra-primer ARMS-PCR technique was performed for DNA genotyping by the use of specific primer pairs.
The susceptibility of OSCC and H19 gene polymorphism sites was further analyzed (rs217727 and rs2107425).
The allele and genotype frequencies of H19 rs2107425 polymorphism were similar between OSCC cases and controls.
The H19 rs217727T allele frequency was significantly higher in OSCC cases (P=0.002), and the polymorphism of H19 rs217727 was associated with OSCC susceptibility in the codominant (OR=6.04, 95%CI=1.70−21.42, P=0.001 for TT genotype), dominant (OR=1.62, 95%CI=1.08−2.43, P=0.01), and recessive (OR=5.32, 95%CI=1.51−18.69, P=0.003) models.
This study showed that rs217727 and OSCC susceptibility were statistically correlated in the Iranian population.
American Psychological Association (APA)
Ghapanchi, Janan& Ranjbar, Zahra& Mokhtari, Mohammad Javad& Koohpeima, Fatemeh& Derakhshan, Maryam& Khademi, Bijan…[et al.]. 2020. The LncRNA H19 rs217727 Polymorphism Is Associated with Oral Squamous Cell Carcinoma Susceptibility in Iranian Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1131787
Modern Language Association (MLA)
Ghapanchi, Janan…[et al.]. The LncRNA H19 rs217727 Polymorphism Is Associated with Oral Squamous Cell Carcinoma Susceptibility in Iranian Population. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1131787
American Medical Association (AMA)
Ghapanchi, Janan& Ranjbar, Zahra& Mokhtari, Mohammad Javad& Koohpeima, Fatemeh& Derakhshan, Maryam& Khademi, Bijan…[et al.]. The LncRNA H19 rs217727 Polymorphism Is Associated with Oral Squamous Cell Carcinoma Susceptibility in Iranian Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1131787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131787