![](/images/graphics-bg.png)
Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women
Joint Authors
Wang, Shanyun
He, Xijun
Meng, Fansu
Pan, Qianyi
Zhang, Lin
Zeng, Jianfeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
High-risk papillomavirus (HR-HPV) testing combined with cytology improves the detection of cervical lesions and increases length of screening intervals.
For a population-based HR-HPV survey, testing automation is in great need.
The Cobas 4800 HPV Test System is a fully automated assay that can simultaneously detect HPV16, HPV18, and other 12 pooled HR-HPV genotypes.
This system has been employed for HR-HPV screening in a number of countries; however, such application in a large population in China has not been documented.
In this study, we employed the Cobas 4800 HPV Test System to detect HR-HPV in cervical cytology specimens collected from a total of 5650 asymptomatic women from a region of South China.
We reported the following: (1) the prevalence of the 14 genotypes of HR-HPV was 12.96%; (2) for those with HR-HPV infection, 2.25% were positive for HPV16, 0.50% for HPV18, 9.15% for pooled 12 HPV types, and 1.06% for multiple HPV infection; and (3) there was no significant difference in the HR-HPV prevalence among different age groups.
HPV16 and HPV18 have been shown to be the predominant HPV types found in cervical cancer patients in some regions in China, indicating that a fully automated assay like the Cobas 4800 HPV Test System is especially valuable for population-based HR-HPV screening in these regions as this assay can concurrently detect HPV16 and HPV18.
American Psychological Association (APA)
Wang, Shanyun& He, Xijun& Meng, Fansu& Pan, Qianyi& Zhang, Lin& Zeng, Jianfeng. 2020. Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1131788
Modern Language Association (MLA)
Wang, Shanyun…[et al.]. Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1131788
American Medical Association (AMA)
Wang, Shanyun& He, Xijun& Meng, Fansu& Pan, Qianyi& Zhang, Lin& Zeng, Jianfeng. Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1131788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131788