Investigation of the Interaction Mechanism between Salbutamol and Human Serum Albumin by Multispectroscopic and Molecular Docking
Joint Authors
Yuqin, Li
Zhao, Ting
Liu, Zihui
Niu, Jingmei
Lv, Baoxing
Xiao, Yuliang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Salbutamol (SBAL), a kind of short-acting beta 2-adrenergic agonist, has been mainly used to treat bronchial asthma and other allergic airway diseases clinically.
In this study, the interaction mechanism between salbutamol and human serum albumin was researched by the multispectral method and molecular docking.
The fluorescence intensity of HSA could be regularly enhanced with the increase of SBAL concentration.
Both the results of the multispectral method and molecular docking showed that SBAL could bind HSA with van der Waals force and hydrogen bonds.
The binding mechanism was further analysed by UV-Vis and synchronous fluorescence spectra.
The contents of the secondary structure of free HSA and SBAL-HSA complex were evaluated using CD spectra.
American Psychological Association (APA)
Zhao, Ting& Liu, Zihui& Niu, Jingmei& Lv, Baoxing& Xiao, Yuliang& Yuqin, Li. 2020. Investigation of the Interaction Mechanism between Salbutamol and Human Serum Albumin by Multispectroscopic and Molecular Docking. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131844
Modern Language Association (MLA)
Zhao, Ting…[et al.]. Investigation of the Interaction Mechanism between Salbutamol and Human Serum Albumin by Multispectroscopic and Molecular Docking. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1131844
American Medical Association (AMA)
Zhao, Ting& Liu, Zihui& Niu, Jingmei& Lv, Baoxing& Xiao, Yuliang& Yuqin, Li. Investigation of the Interaction Mechanism between Salbutamol and Human Serum Albumin by Multispectroscopic and Molecular Docking. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131844