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Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms
Joint Authors
Jiang, Yi
Zhou, Xiao
Li, Qiuyun
Yang, Huawei
Wei, Changyuan
Huang, Zhen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Arachidonate lipoxygenases (ALOX) have been implicated in playing a critical role in tumorigenesis, development, and metastasis.
We previously reported that ALOX12 is involved in breast cancer chemoresistance.
In this study, we demonstrate that the ALOX5 activation correlates with the HER2 expression and mediates breast cancer growth and migration.
We found that the ALOX5 expression and activity were upregulated in breast cancer patients, particularly in those tissues with HER2-positive.
ALOX5 upregulation was also observed in HER2-positive breast cancer cells.
In contrast, HER2 inhibition led to decreased expression and activity of ALOX5 but not ALOX5AP, suggesting that HER2 specifically regulates the ALOX5 expression and activity in breast cancer cells.
We further demonstrated that ALOX5 is important for breast cancer biological activities with the predominant roles in growth and migration, likely through RhoA, focal adhesion, and PI3K/Akt/mTOR signaling but not epithelial mesenchymal transition (EMT).
Our work is the first to report a correlation between the ALOX5 activity and HER2 overexpression in breast cancer.
Our findings also highlight the therapeutic value of inhibiting ALOX5 in breast cancer, particularly those patients with the HER2 overexpression.
American Psychological Association (APA)
Zhou, Xiao& Jiang, Yi& Li, Qiuyun& Huang, Zhen& Yang, Huawei& Wei, Changyuan. 2020. Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131852
Modern Language Association (MLA)
Zhou, Xiao…[et al.]. Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1131852
American Medical Association (AMA)
Zhou, Xiao& Jiang, Yi& Li, Qiuyun& Huang, Zhen& Yang, Huawei& Wei, Changyuan. Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131852