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Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets
Joint Authors
Wang, Qiankun
Wang, Mengyao
Liu, Chun
Huang, Longhui
Gao, Yun
Yu, Mei
Li, Xiaoping
Zhao, Shuhong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
As one of the main environmental stressors commonly found in closed pig houses, ammonia poses high risks to the well-being of humans and animals.
This study is aimed at assessing the toxicity of ammonia exposure (80 ppm for 12 days) on the nasal mucosa in piglets.
Firstly, we found that after ammonia exposure, the number of white blood cells significantly increased and the serum levels of cytokine IL-4 were significantly decreased.
Then, histological analyses showed significant thickening of nasal mucosa and excessive mucus production in the exposure group.
Finally, RNA-seq analyses demonstrated that the ammonia exposure disturbed the transcriptome of nasal mucosa which revealed 176 upregulated genes and 426 downregulated genes.
GO and KEGG pathway enrichment analysis of the DEGs showed that the upregulated genes were mainly related to neutrophil chemotaxis and immune response, while 80 out of the 426 downregulated genes including CCDCs, CFAPs, DNAHs, and TEKTs were enriched in the microtubule cytoskeleton and cilium morphogenesis/movement.
All these results indicated that ammonia exposure induces nasal mucosal hyperplasia and cilia dysfunction, as well as a systemic inflammatory response in piglets.
These findings provide new evidence for understanding the damage mechanism of ammonia on the nasal mucosa.
American Psychological Association (APA)
Wang, Qiankun& Wang, Mengyao& Liu, Chun& Huang, Longhui& Gao, Yun& Yu, Mei…[et al.]. 2020. Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131859
Modern Language Association (MLA)
Wang, Qiankun…[et al.]. Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1131859
American Medical Association (AMA)
Wang, Qiankun& Wang, Mengyao& Liu, Chun& Huang, Longhui& Gao, Yun& Yu, Mei…[et al.]. Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131859