Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus
Joint Authors
Zhao, Hui
Ni, Xiaoqing
Gu, Yunjuan
Wang, Xinlei
Sun, Yi
Zhu, Minxia
Chang, Renan
Su, Jianyou
Huang, Hua
Cui, Shiwei
Yuan, Jin
Yuan, Jie
OuYang, Rong
Zhang, Rongping
Chen, Wei
Sun, Yezi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Type 2 diabetes mellitus (T2DM) carries a high risk of hepatocellular carcinoma (HCC).
Both serum fibroblast growth factor 19 (FGF19) and bile acid concentrations are associated with T2DM and HCC.
We aimed at evaluating the relationships between FGF19 and bile acid concentrations and HCC in patients with T2DM.
Methods.
Twenty-seven healthy volunteers (control group), 27 patients with T2DM (T2DM group), 16 patients with newly diagnosed HCC (HCC group), and 10 T2DM patients with newly diagnosed HCC (T2DM-HCC group) were studied at the Affiliated Hospital of Nantong University between June 2016 and June 2017.
The serum concentrations of serum FGF19 and total bile acids (TBA) were measured in all the participants.
Correlation analysis and multiple stepwise regression analysis of the FGF19 and TBA concentrations were performed in all the participants and in the four groups.
Results.
The concentrations of FGF19 were 220.5 pg/ml, 185.1 pg/ml, 115.8 pg/ml, and 70.4 pg/ml in the HCC, T2DM-HCC, control, and T2DM groups, respectively (p<0.001), and the TBA concentrations were 21.75 μmol/l, 14.25 μmol/l, 3.6 μmol/l, and 3.1 μmol/l (p<0.001).
There were positive correlations between the FGF19 and TBA concentrations across all the participants (r = 0.777; p<0.001), and in the control (r = 0.400; p=0.039), T2DM (r = 0.477; p=0.012), HCC (r = 0.684; p=0.003), and T2DM-HCC (r = 0.673; p=0.033) groups.
Conclusions.
Simultaneous increase of serum FGF19 and TBA levels may be used as indicators of HCC screening at early stage in patients with T2DM.
American Psychological Association (APA)
Sun, Yi& Zhu, Minxia& Zhao, Hui& Ni, Xiaoqing& Chang, Renan& Su, Jianyou…[et al.]. 2020. Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131889
Modern Language Association (MLA)
Sun, Yi…[et al.]. Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131889
American Medical Association (AMA)
Sun, Yi& Zhu, Minxia& Zhao, Hui& Ni, Xiaoqing& Chang, Renan& Su, Jianyou…[et al.]. Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131889