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ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents
Joint Authors
Khalifa, Moad
Few, Ling Ling
See Too, Wei Cun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Novel antimicrobial agents are crucial to combat antibiotic resistance in pathogenic bacteria.
Choline kinase (ChoK) in bacteria catalyzes the synthesis of phosphorylcholine, which is subsequently incorporated into the cell wall or outer membrane.
In certain species of bacteria, phosphorylcholine is also used to synthesize membrane phosphatidylcholine.
Numerous human ChoK inhibitors (ChoKIs) have been synthesized and tested for anticancer properties.
Inhibition of S.
pneumoniae ChoK by human ChoKIs showed a promising effect by distorting the cell wall and retarded the growth of this pathogen.
Comparison of amino acid sequences at the catalytic sites of putative choline kinases from pathogenic bacteria and human enzymes revealed striking sequence conservation that supports the potential application of currently available ChoKIs for inhibiting bacterial enzymes.
We also propose the combined use of ChoKIs and nanoparticles for targeted delivery to the pathogen while shielding the human host from any possible side effects of the inhibitors.
More research should focus on the verification of putative bacterial ChoK activities and the characterization of ChoKIs with active enzymes.
In conclusion, the presence of ChoK in a wide range of pathogenic bacteria and the distinct function of this enzyme has made it an attractive drug target.
This review highlighted the possibility of “choking” bacterial ChoKs by using human ChoKIs.
American Psychological Association (APA)
Khalifa, Moad& Few, Ling Ling& See Too, Wei Cun. 2020. ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1131973
Modern Language Association (MLA)
Khalifa, Moad…[et al.]. ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1131973
American Medical Association (AMA)
Khalifa, Moad& Few, Ling Ling& See Too, Wei Cun. ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1131973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131973