Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis
Joint Authors
Sandamali, Jayasinghe Arachchige Nirosha
Hewawasam, Ruwani Punyakanthi
Fernando, Madappuli Arachchige Chaminda Sri Sampath
Jayatilaka, Kamani Ayoma Perera Wijewardana
Madurawe, Ranji Duleep
Sathananthan, Periyasamy Pillai
Ekanayake, Upul
Horadugoda, Jayamini
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Anthracycline-induced cardiotoxicity has never been investigated in Sri Lanka.
Therefore, this study was conducted to determine the prevalence of anthracycline-induced cardiotoxicity in breast cancer patients using echocardiographic findings.
A prospective cohort study was performed.
All newly diagnosed breast cancer patients who were administered with anthracycline and cyclophosphamide (AC schedule) for the first time were enrolled in the study.
In the hospital setting, anthracycline is administered only as a combination therapy, and only this combination was selected to limit the effect of other cardiotoxic chemotherapy agents.
Records of echocardiography were obtained: one day before anthracycline chemotherapy (baseline), one day after the first chemotherapy dose, one day after the last chemotherapy dose, and six months after the completion of anthracycline chemotherapy.
Following parameters were recorded from the echocardiography results: ejection fraction (EF, %), fractioning shortening (FS, %), posterior wall thickness, left ventricle (PWT, mm), the thickness of interventricular septum (IVS, mm), left ventricular end-diastolic diameter (LVEDD, mm), and left ventricular end-systolic diameter (LVESD, mm).
Statistical analysis of the echocardiography results was performed using ANOVA at four stages.
A p value <0.05 was considered significant.
Subclinical cardiac dysfunction was defined as a fall of EF >10% during the follow-up echocardiography.
There was no significant change (p>0.05) between the baseline echocardiographic parameters and one day after the 1st anthracycline dose.
However, significant differences (p<0.05) were observed between the baseline echocardiographic parameters and one day after the last anthracycline dose and six months after the completion of anthracycline therapy with a gradual and progressive deterioration in functional parameters including EF, FS, PWT, and IVS over time.
There were 65 patients out of 196 (33.16%) who developed subclinical cardiac dysfunction six months after the completion of anthracycline chemotherapy.
The prevalence of subclinical anthracycline-induced cardiotoxicity was relatively higher in these patients.
An equation was also developed based on left ventricular ejection fraction (LVEF) to predict the anthracycline-induced cardiotoxicity of a patient six months after the completion of anthracycline chemotherapy.
We believe that this will help in the monitoring of patients who undergo anthracycline therapy for cardiotoxicity.
It is recommended to carry out a long-term follow-up to detect early-onset chronic progressive cardiotoxicity in all patients who were treated with anthracycline therapy.
American Psychological Association (APA)
Sandamali, Jayasinghe Arachchige Nirosha& Hewawasam, Ruwani Punyakanthi& Fernando, Madappuli Arachchige Chaminda Sri Sampath& Jayatilaka, Kamani Ayoma Perera Wijewardana& Madurawe, Ranji Duleep& Sathananthan, Periyasamy Pillai…[et al.]. 2020. Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132007
Modern Language Association (MLA)
Sandamali, Jayasinghe Arachchige Nirosha…[et al.]. Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132007
American Medical Association (AMA)
Sandamali, Jayasinghe Arachchige Nirosha& Hewawasam, Ruwani Punyakanthi& Fernando, Madappuli Arachchige Chaminda Sri Sampath& Jayatilaka, Kamani Ayoma Perera Wijewardana& Madurawe, Ranji Duleep& Sathananthan, Periyasamy Pillai…[et al.]. Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132007