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A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs
Joint Authors
Choi, Sanghun
Miyawaki, Shinjiro
Lin, Ching-Long
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study aims to investigate the effect of altered structures and functions in severe asthma on particle deposition by using computational fluid dynamics (CFD) models.
Airway geometrical models of two healthy subjects and two severe asthmatics were reconstructed from computed tomography (CT) images.
Subject-specific flow boundary conditions were obtained by image registration to account for regional functional alterations of severe asthmatics.
A large eddy simulation (LES) model for transitional and turbulent flows was applied to simulate airflows, and particle transport simulations were then performed for 2.5, 5, and 10 μm particles using CFD-predicted flow fields.
Compared to the healthy subjects, the severe asthmatics had a smaller air-volume change in the lower lobes and a larger air-volume change in the upper lobes.
Both severe asthmatics had smaller airway circularity (Cr), but one of them had a significant reduction of hydraulic diameter (Dh).
In severe asthmatics, the larger air-volume change in the upper lobes resulted in more particles in the upper lobes, especially for the small 2.5 μm particles.
The structural alterations measured by Cr and Dh were associated with a higher particle deposition.
Dh was found to be the most important metric which affects the specific location of particle deposition.
This study demonstrates the relationship of CT-based structural and functional alterations in severe asthma with flow and particle dynamics.
American Psychological Association (APA)
Choi, Sanghun& Miyawaki, Shinjiro& Lin, Ching-Long. 2018. A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1132097
Modern Language Association (MLA)
Choi, Sanghun…[et al.]. A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1132097
American Medical Association (AMA)
Choi, Sanghun& Miyawaki, Shinjiro& Lin, Ching-Long. A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1132097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132097