RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation
Joint Authors
Qiu, Kaixin
Wang, Shuai
Wang, Xin
Wang, Fengting
Wu, Yili
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Amyloid-β protein (Aβ) is the main component of neuritic plaques, the pathological hallmark of Alzheimer’s disease (AD).
β-site APP cleaving enzyme 1 (BACE1) is a major β-secretase contributing to Aβ generation.
β-site APP cleaving enzyme 2 (BACE2), the homolog of BACE1, is not only a θ-secretase but also a conditional β-secretase.
Previous studies showed that regulator of calcineurin 1 (RCAN1) is markedly increased by AD and promotes BACE1 expression.
However, the role of RCAN1 in BACE2 regulation remains elusive.
Here, we showed that RCAN1 increases BACE2 protein levels.
Moreover, RCAN1 inhibits the turnover of BACE2 protein.
Furthermore, RCAN1 attenuates proteasome-mediated BACE2 degradation, but not lysosome-mediated BACE2 degradation.
Taken together, our work indicates that RCAN1 inhibits BACE2 turnover by attenuating proteasome-mediated BACE2 degradation.
It advances our understanding of BACE2 regulation and provides a potential mechanism of BACE2 dysregulation in AD.
American Psychological Association (APA)
Qiu, Kaixin& Wang, Shuai& Wang, Xin& Wang, Fengting& Wu, Yili. 2020. RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132139
Modern Language Association (MLA)
Qiu, Kaixin…[et al.]. RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132139
American Medical Association (AMA)
Qiu, Kaixin& Wang, Shuai& Wang, Xin& Wang, Fengting& Wu, Yili. RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132139