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SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma
Joint Authors
Su, Qi-Sheng
Zhang, Liqian
Zhang, Zunni
Qin, Liuqun
Shi, Xiang
Mo, Wuning
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The purpose of this study was to explore the relationship between stromal cell-derived factor 2-like 1 (SDF2L1) and nasopharyngeal carcinoma (NPC).
12 NPC tissues and 12 chronic nasopharyngitis tissues were involved in our study.
Quantitative real-time PCR (qRT-PCR) and Western Blot were utilized to detect the expression of SDF2L1.
Besides, immunofluorescence analysis was utilized to determine the protein expression of 97 paraffin-embedded NPC tissues and 58 nasopharyngitis tissues.
Biological functional experiment included Cell Counting Kit-8 (CCK-8) assay, cell clone formation assay, cell scratch migration assay, Transwell migration assay, and Transwell invasion assay.
All data were analyzed by SPSS.
Results showed that downexpression of SDF2L1 was prominently present in NPC tissues and cells.
Furthermore, silencing the expression of SDF2L1 promoted NPC proliferation, migration, and invasion in vitro, while overexpression of SDF2L1 has the opposite effect.
In conclusion, SDF2L1 may act as a cancer suppressor gene, play a crucial role in the occurrence and development of NPC, and be a new therapeutic target or prognostic indicator for NPC.
American Psychological Association (APA)
Zhang, Liqian& Zhang, Zunni& Qin, Liuqun& Shi, Xiang& Su, Qi-Sheng& Mo, Wuning. 2020. SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132199
Modern Language Association (MLA)
Zhang, Liqian…[et al.]. SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132199
American Medical Association (AMA)
Zhang, Liqian& Zhang, Zunni& Qin, Liuqun& Shi, Xiang& Su, Qi-Sheng& Mo, Wuning. SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132199