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Immune-Related lncRNA Risk Signatures Predict Survival of IDH Wild-Type and MGMT Promoter Unmethylated Glioblastoma
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Glioblastoma is the most malignant grade of glioma, and it is also the most common primary tumor in the brain.
Immunotherapy is a kind of precise tumor treatment.
However, there are limited studies about immune-related lncRNA.
This study is aimed at analyzing immune-related lncRNAs in glioblastoma and screening out prognostic factors, providing new potential targets for glioblastoma immunology research.
Material and Methods.
Gene expression data and clinical data of IDH wild-type with MGMT promoter unmethylated glioblastoma were acquired from the TCGA and CGGA databases.
Immune-related lncRNAs were identified with the help of data from the InnateDB database.
Immune prognostic factors were recognized by Cox regression analysis.
GSEA analysis pursued their potential functions.
Results.
We found 318 immune-related lncRNAs.
Among them, there were 137 immune-related lncRNAs that were upregulated and 181 that were downregulated.
15 prognostic lncRNAs were identified by Cox regression, and a total of 6 molecules were included in the following risk scoring model.
GSEA showed that these lncRNAs participated in functions such as protein digestion and absorption and the PPAR signaling pathway.
Conclusion.
There are limited studies about immune regulation mechanisms of lncRNA in IDH wild-type with MGMT promoter unmethylated glioblastoma.
The identified immune-related lncRNAs in glioblastoma might contribute new targets and research directions for immunological molecular studies of glioblastoma.
American Psychological Association (APA)
Li, Xiaozhi& Meng, Yutong. 2020. Immune-Related lncRNA Risk Signatures Predict Survival of IDH Wild-Type and MGMT Promoter Unmethylated Glioblastoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132204
Modern Language Association (MLA)
Li, Xiaozhi& Meng, Yutong. Immune-Related lncRNA Risk Signatures Predict Survival of IDH Wild-Type and MGMT Promoter Unmethylated Glioblastoma. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1132204
American Medical Association (AMA)
Li, Xiaozhi& Meng, Yutong. Immune-Related lncRNA Risk Signatures Predict Survival of IDH Wild-Type and MGMT Promoter Unmethylated Glioblastoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132204