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Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Dengue virus is a mosquito borne Flavivirus and the most prevalent arbovirus in tropical and subtropical regions around the world.
The incidence of dengue has increased drastically over the last few years at an alarming rate.
The clinical manifestation of dengue ranges from asymptomatic infection to severe dengue.
Even though the viral kinetics of dengue infection is lacking, innate immune response and humoral immune response are thought to play a major role in controlling the virus count.
Here, we developed a computer simulation mathematical model including both innate and adaptive immune responses to study the within-host dynamics of dengue virus infection.
A sensitivity analysis was carried out to identify key parameters that would contribute towards severe dengue.
A detailed stability analysis was carried out to identify relevant range of parameters that contributes to different outcomes of the infection.
This study provides a qualitative understanding of the biological factors that can explain the viral kinetics during a dengue infection.
American Psychological Association (APA)
Perera, S. D.& Perera, S. S. N.. 2018. Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1132219
Modern Language Association (MLA)
Perera, S. D.& Perera, S. S. N.. Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1132219
American Medical Association (AMA)
Perera, S. D.& Perera, S. S. N.. Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1132219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132219