Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis
Joint Authors
Deng, Li
Niu, Geng-Ming
Ren, Jun
Ke, Chong-Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Homeostasis of membrane phospholipids plays an important role in cell oncogenesis and cancer progression.
The flippase ATPase class I type 8b member 1 (ATP8B1), one of the P4-ATPases, translocates specific phospholipids from the exoplasmic to the cytoplasmic leaflet of membranes.
ATP8B1 is critical for maintaining the epithelium membrane stability and polarity.
However, the prognostic values of ATP8B1 in colorectal cancer (CRC) patients remain unclear.
We analyzed transcriptomics, genomics, and clinical data of CRC samples from The Cancer Genome Atlas (TCGA).
ATP8B1 was the only potential biomarker of phospholipid transporters in CRC.
Its prognostic value was also validated with the data from the Gene Expression Omnibus (GEO).
Compared to the normal group, the expression of ATP8B1 was downregulated in the tumor group and the CRC cell lines, which declined with disease progression.
The lower expression level of ATP8B1 was also significantly associated with worse survival outcomes in both the discovery samples (359 patients) and the validation samples (566 patients).
In multivariate analyses, low ATP8B1 levels predicted unfavorable OS (adjusted HR 1.512, 95% CI: 1.069-2.137; P=0.019) and were associated with poor progress-free interval (PFI) (adjusted HR: 1.62, 95% CI: 1.207-2.174; P=0.001).
The pathway analysis results showed that the underexpression of ATP8B1 was negatively associated with phospholipid transport, phospholipid metabolic process, and cell-cell adherent junction and positively associated with the epithelial-mesenchymal transition in CRC.
Our analysis suggests that ATP8B1 is a potential cancer suppressor in CRC patients and may offer new strategies for CRC therapy.
American Psychological Association (APA)
Deng, Li& Niu, Geng-Ming& Ren, Jun& Ke, Chong-Wei. 2020. Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132233
Modern Language Association (MLA)
Deng, Li…[et al.]. Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1132233
American Medical Association (AMA)
Deng, Li& Niu, Geng-Ming& Ren, Jun& Ke, Chong-Wei. Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132233