ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3KAKT Pathway
Joint Authors
Li, Qi
Xiu, Lijuan
Yue, Xiaoqiang
Yu, Jiahui
Song, Shangjin
Jiao, Jianpeng
Liu, Xuan
Zhu, Huirong
Sun, Dazhi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In recent years, traditional Chinese medicine has played an important role in the treatment of gastric cancer in China.
ZiYinHuaTan (ZYHT) recipe was developed for advanced gastric cancer and had shown its promising value in the clinic.
In this study, we explore the effect of ZYHT on gastric cancer in vitro and in vivo.
ZYHT can inhibit tumor growth and improve the general condition of mice in subcutaneous transplantation nude mice models of gastric cancer.
And ZYHT can also inhibit cell proliferation and blocked the cells in G0/G1 to induce cell apoptosis in HGC27 and MGC803 cells.
Then, network pharmacology analysis showed that ZYHT may exert antitumor effect mainly through PI3K/AKT signaling pathway.
Furthermore, the expression of PI3K, p-Akt, CyclinD1, and Bcl-2 was detected in vitro and in vivo.
The results showed that ZYHT could decrease the expression of PI3K, CyclinD1, and Bcl-2 both in vitro and in vivo.
These results suggested that ZYHT could be used as a method for the treatment of developed gastric cancer.
American Psychological Association (APA)
Yu, Jiahui& Song, Shangjin& Jiao, Jianpeng& Liu, Xuan& Zhu, Huirong& Xiu, Lijuan…[et al.]. 2020. ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3KAKT Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132238
Modern Language Association (MLA)
Yu, Jiahui…[et al.]. ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3KAKT Pathway. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132238
American Medical Association (AMA)
Yu, Jiahui& Song, Shangjin& Jiao, Jianpeng& Liu, Xuan& Zhu, Huirong& Xiu, Lijuan…[et al.]. ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3KAKT Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132238