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Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study
Joint Authors
Bachir, Wesam
Ismael, Fatimah S.
Amasha, Hani
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors.
This should be achieved in parallel with minimal damage to the nearby intact tissues.
To that end, clinical iPDT can be attained using cylindrical diffusing optical fibers (CDFs) as light sources.
In this work, we optimize output CDF powers in order to deliver a prescribed light dose to a spherical volume such as a tumor node.
Methods.
Four CDFs are placed vertically inside the tumor node.
The fluence rate is calculated using the diffusion equation.
Therapeutic target dose is (20-50) J·cm-2.
The optical properties (μa=0.085 cm−1, μs′=16 cm−1) of a breast tumor and the treatment time of 150 sec are used to calculate the fluence rate.
Results.
For four CDFs, the therapeutic target dose (20-50) J·cm-2 is delivered to more than 90%.
This is the ratio of the total points that receive the target dose in proportion to the total points in the volume of the node of 3 cm in diameter, whereas, in larger nodes, the ratio is decreased to approximately 67%.
Five CDFs are required to improve this ratio by more than 10%.
Conclusion.
Optimizing delivered powers enables the distribution of the therapeutic dose uniformly in the medium.
In addition, this simulation study represents an essential part of a development dosimetry system for measuring and controlling the optical dose in the breast tumors.
American Psychological Association (APA)
Ismael, Fatimah S.& Amasha, Hani& Bachir, Wesam. 2020. Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132274
Modern Language Association (MLA)
Ismael, Fatimah S.…[et al.]. Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1132274
American Medical Association (AMA)
Ismael, Fatimah S.& Amasha, Hani& Bachir, Wesam. Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132274