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BRWSP: Predicting circRNA-Disease Associations Based on Biased Random Walk to Search Paths on a Multiple Heterogeneous Network
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The circular RNAs (circRNAs) have significant effects on a variety of biological processes, the dysfunction of which is closely related to the emergence and development of diseases.
Therefore, identification of circRNA-disease associations will contribute to analysing the pathogenesis of diseases.
Here, we present a computational model called BRWSP to predict circRNA-disease associations, which searches paths on a multiple heterogeneous network based on biased random walk.
Firstly, BRWSP constructs a multiple heterogeneous network by using circRNAs, diseases, and genes.
Then, the biased random walk algorithm runs on the multiple heterogeneous network to search paths between circRNAs and diseases.
Finally, the performance of BRWSP is significantly better than the state-of-the-art algorithms.
Furthermore, BRWSP further contributes to the discovery of novel circRNA-disease associations.
American Psychological Association (APA)
Lei, Xiujuan& Zhang, Wenxiang. 2019. BRWSP: Predicting circRNA-Disease Associations Based on Biased Random Walk to Search Paths on a Multiple Heterogeneous Network. Complexity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1132275
Modern Language Association (MLA)
Lei, Xiujuan& Zhang, Wenxiang. BRWSP: Predicting circRNA-Disease Associations Based on Biased Random Walk to Search Paths on a Multiple Heterogeneous Network. Complexity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1132275
American Medical Association (AMA)
Lei, Xiujuan& Zhang, Wenxiang. BRWSP: Predicting circRNA-Disease Associations Based on Biased Random Walk to Search Paths on a Multiple Heterogeneous Network. Complexity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1132275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132275