The Identification and Verification of Key Long Noncoding RNAs in Ischemic Stroke
Joint Authors
Chen, Xia
Bian, Yaoyao
Xu, Houxi
Zhang, Jinzhi
Ma, Yuzhu
Gu, Jialin
Jing, Xinyue
Lu, Shengfeng
Yang, Wenguo
Fu, Shuping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Stroke is a neurological disease with high rates of mortality and disability.
The pathogenesis of stroke is acute focal injury of the central nervous system, leading to impaired neural function.
Ischemic stroke accounts for the majority of cases.
At present, the exact molecular mechanism of ischemic stroke remains unclear.
Studies have shown that long noncoding RNAs (lncRNAs) have an important regulatory role in biological processes, participating in the regulation of transcription and affecting the processing and splicing of mRNAs.
Abnormal lncRNA expression is associated with various diseases, including diseases of the nervous system.
To identify and verify the key lncRNAs in ischemic stroke, we downloaded gene expression data from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO) and obtain differentially expressed lncRNAs, miRNAs, and mRNAs by bioinformatics analysis.
Cytoscape was used to reconstruct a lncRNA-miRNA-mRNA network on the basis of the competitive endogenous RNA theory.
We performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the mRNAs regulated by lncRNAs in the lncRNA-miRNA-mRNA network.
The resulting lncRNA-miRNA-mRNA network was composed of 91 lncRNA nodes, 70 mRNA nodes, 21 miRNA nodes, and 288 edges.
GO analysis and KEGG pathway analysis have shown that 191 GO terms and 23 KEGG pathways were enriched.
Finally, we found that four key lncRNAs were highly correlated with ischemic stroke and could be used as potential new targets for treatment.
American Psychological Association (APA)
Xu, Houxi& Zhang, Jinzhi& Ma, Yuzhu& Gu, Jialin& Jing, Xinyue& Lu, Shengfeng…[et al.]. 2020. The Identification and Verification of Key Long Noncoding RNAs in Ischemic Stroke. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132319
Modern Language Association (MLA)
Xu, Houxi…[et al.]. The Identification and Verification of Key Long Noncoding RNAs in Ischemic Stroke. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132319
American Medical Association (AMA)
Xu, Houxi& Zhang, Jinzhi& Ma, Yuzhu& Gu, Jialin& Jing, Xinyue& Lu, Shengfeng…[et al.]. The Identification and Verification of Key Long Noncoding RNAs in Ischemic Stroke. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132319