Prognostic Value and Clinicopathological Features of MicroRNA-206 in Various Cancers: A Meta-Analysis
Joint Authors
Liu, Rongqiang
Yu, Yajie
Zheng, Shiyang
Peng, Shengjia
Fang, Jianwen
Tan, Siwen
Guo, Zhihua
Shao, Yi
Yao, Fan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It has been reported that microRNA-206(miR-206) plays an important role in cancers and could be used as a prognostic biomarker.
However, the results are controversial.
Therefore, we summarize all available evidence and present a meta-analysis to estimate the prognostic value of miR-206 in various cancers.
The relevant studies were collected by searching PubMed, EMBASE, and Web of Science databases until August 21, 2020.
Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the association between miR-206 and survival results and clinicopathologic features.
Sources of heterogeneity were investigated by subgroup analysis and sensitivity analysis.
Publication bias was evaluated using Egger’s test.
Twenty articles involving 2095 patients were included in the meta-analysis.
The pooled HR showed that low miR-206 expression was significantly associated with unfavourable overall survival (OS) (HR=2.03, 95 CI%: 1.53-2.70, P<0.01).
In addition, we found that low miR-206 expression predicted significantly negative association with tumor stage (III-IV VS.
I-II) (OR=4.20, 95% CI: 2.17-8.13, P<0.01), lymph node status (yes VS.
no) (OR=3.58, 95%: 1.51-8.44, P=0.004), distant metastasis (yes VS.
no) (OR=3.19, 95%: 1.07-9.50, P=0.038), and invasion depth (T3+T4 vs.
T2+T1) (OR=2.43, 95%: 1.70-3.49, P<0.01).
miR-206 can be used as an effective prognostic indicator in various cancers.
Further investigations are warranted to validate the present results.
American Psychological Association (APA)
Liu, Rongqiang& Zheng, Shiyang& Peng, Shengjia& Yu, Yajie& Fang, Jianwen& Tan, Siwen…[et al.]. 2020. Prognostic Value and Clinicopathological Features of MicroRNA-206 in Various Cancers: A Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132377
Modern Language Association (MLA)
Liu, Rongqiang…[et al.]. Prognostic Value and Clinicopathological Features of MicroRNA-206 in Various Cancers: A Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1132377
American Medical Association (AMA)
Liu, Rongqiang& Zheng, Shiyang& Peng, Shengjia& Yu, Yajie& Fang, Jianwen& Tan, Siwen…[et al.]. Prognostic Value and Clinicopathological Features of MicroRNA-206 in Various Cancers: A Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132377