A Multistage Feedback Control Strategy for Producing 1,3-Propanediol in Microbial Continuous Fermentation

Abstract EN

In this paper, we consider a multistage feedback control strategy for producing 1,3-propanediol in microbial continuous fermentation.

Both the dilution rate and the concentration of glycerol in the input feed are used as control variables, and these variables are further assumed to be in the form of a linear combination of biomass and glycerol concentrations.

Unlike the general form of linear feedback control, the coefficients of linear combination are continuous functions with respect to time.

Inspired by the control parameterization method, we use the piecewise-constant functions to approximate the coefficient functions; then we get the multistage feedback control law by solving nonlinear mathematical programming problems.

Numerical results indicate the flexibility and effectiveness of our strategy.