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Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
Joint Authors
Machado-Junior, Pedro A.
Araújo, Natália P. S.
Souza, Ana B. F.
Castro, Thalles F.
Oliveira, Michel
Costa, Guilherme P.
Matos, Natália A.
Vieira, Paula M. A.
Talvani, André
Bezerra, Frank S.
Cangussú, Sílvia D.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases.
Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases.
This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure.
Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG).
CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized.
Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG.
These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.
American Psychological Association (APA)
Machado-Junior, Pedro A.& Araújo, Natália P. S.& Souza, Ana B. F.& Castro, Thalles F.& Oliveira, Michel& Costa, Guilherme P.…[et al.]. 2020. Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132410
Modern Language Association (MLA)
Machado-Junior, Pedro A.…[et al.]. Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132410
American Medical Association (AMA)
Machado-Junior, Pedro A.& Araújo, Natália P. S.& Souza, Ana B. F.& Castro, Thalles F.& Oliveira, Michel& Costa, Guilherme P.…[et al.]. Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132410