Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial IschemiaReperfusion Injury
Joint Authors
Sun, Zhaoqing
Yu, Tongtong
Jiao, Yundi
He, Dongxu
Wu, Jiake
Duan, Weili
Sun, Zhijun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Circular RNAs (circRNAs) play important roles in cellular physiology.
The association between circRNAs and myocardial ischemia/reperfusion (I/R) injury remains largely unknown.
The aim of this study was to test the effects of myocardial I/R circRNA expression and explore the potential roles of these circRNAs.
CircRNAs were screened by high-throughput sequencing, and the expression of dysregulated circRNAs was further validated using quantitative real-time polymerase chain reaction.
Nineteen upregulated and 20 downregulated circRNAs were identified.
Gene Ontology analysis indicated that the dysregulated transcripts were associated with fundamental pathophysiologic processes.
Kyoto Encyclopedia of Genes and Genomes pathway analysis showed significant changes in adherens junction, the HIF-1 signaling pathway, the cell cycle, and the FoxO signaling pathway which have a close relationship with myocardial I/R injury.
The circRNA-miRNA analysis demonstrated the broad potential of the differentially expressed circRNAs to regulate target genes by acting on the miRNAs.
This study provides a foundation for understanding the roles and mechanisms of circRNAs in myocardial I/R injury.
American Psychological Association (APA)
Sun, Zhaoqing& Yu, Tongtong& Jiao, Yundi& He, Dongxu& Wu, Jiake& Duan, Weili…[et al.]. 2020. Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial IschemiaReperfusion Injury. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132447
Modern Language Association (MLA)
Sun, Zhaoqing…[et al.]. Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial IschemiaReperfusion Injury. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132447
American Medical Association (AMA)
Sun, Zhaoqing& Yu, Tongtong& Jiao, Yundi& He, Dongxu& Wu, Jiake& Duan, Weili…[et al.]. Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial IschemiaReperfusion Injury. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132447