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Study of Osteoarthritis-Related Hub Genes Based on Bioinformatics Analysis
Joint Authors
Li, Zhaoyan
Zhong, Lei
Zhu, Zhengqing
Li, Ronghang
Liu, Yuzhe
Chen, Xiangrun
Huang, Lanfeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Osteoarthritis (OA) is a common cause of morbidity and disability worldwide.
However, the pathogenesis of OA is unclear.
Therefore, this study was conducted to characterize the pathogenesis and implicated genes of OA.
The gene expression profiles of GSE82107 and GSE55235 were downloaded from the Gene Expression Omnibus database.
Altogether, 173 differentially expressed genes including 68 upregulated genes and 105 downregulated genes in patients with OA were selected based on the criteria of ∣log fold‐change∣>1 and an adjusted p value < 0.05.
Protein-protein interaction network analysis showed that FN1, COL1A1, IGF1, SPP1, TIMP1, BGN, COL5A1, MMP13, CLU, and SDC1 are the top ten genes most closely related to OA.
Quantitative reverse transcription-polymerase chain reaction showed that the expression levels of COL1A1, COL5A1, TIMP1, MMP13, and SDC1 were significantly increased in OA.
This study provides clues for the molecular mechanism and specific biomarkers of OA.
American Psychological Association (APA)
Zhu, Zhengqing& Zhong, Lei& Li, Ronghang& Liu, Yuzhe& Chen, Xiangrun& Li, Zhaoyan…[et al.]. 2020. Study of Osteoarthritis-Related Hub Genes Based on Bioinformatics Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132459
Modern Language Association (MLA)
Zhu, Zhengqing…[et al.]. Study of Osteoarthritis-Related Hub Genes Based on Bioinformatics Analysis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132459
American Medical Association (AMA)
Zhu, Zhengqing& Zhong, Lei& Li, Ronghang& Liu, Yuzhe& Chen, Xiangrun& Li, Zhaoyan…[et al.]. Study of Osteoarthritis-Related Hub Genes Based on Bioinformatics Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132459