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Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways
Joint Authors
Zhu, Liang
Wu, Zhiqiang
He, Qin
Xu, Bin
Yu, Zhiyi
Hu, Zhuyuan
Zhou, Shishi
Chen, Meiqin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gefitinib is a tyrosine kinase inhibitor of EGFR (epidermal growth factor receptor) and represents the first-line treatment for EGFR mutation patients with NSCLC (non-small-cell lung cancer) therapeutics.
However, NSCLC patients are inclined to develop acquired gefitinib drug resistance through nowadays, unarticulated mechanisms of chemoresistance.
Here, we investigated the role of TF (Trifolium flavonoids) on sensitizing gefitinib resistance in NSCLC cells and revealed its potential mechanism of action.
We demonstrated that TF exerted significantly potential chemosensitivity in gefitinib resistant NSCLC cells.
MTT assay and cytological methods were used to analyze cell viability and apoptosis in NSCLC cell line PC-9R.
Both TF and gefitinib suppressed PC-9R cell growth in a dose-dependent manner.
Subtoxic concentrations of TF did significantly augment gefitinib-induced apoptosis in PC-9R cell line.
The TF promoted chemosensitivity was major mediated by the PARP and caspases activation.
Meanwhile, the TF promoted chemosensitivity also decreased the expression of Bcl-2 and Mcl-1.
Finally, TF significantly reduced the phosphorylation levels of STAT3 and ERK.
Altogether, the results of the present study indicated the potential mechanisms of chemosensitivity of TF in gefitinib-induced apoptosis of NSCLC by downregulating ERK and STAT3 signaling pathways and Bcl2 and Mcl-1 expression and a promising application of TF in therapy of NSCLC with gefitinib resistant.
American Psychological Association (APA)
Wu, Zhiqiang& Xu, Bin& Yu, Zhiyi& He, Qin& Hu, Zhuyuan& Zhou, Shishi…[et al.]. 2020. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132547
Modern Language Association (MLA)
Wu, Zhiqiang…[et al.]. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132547
American Medical Association (AMA)
Wu, Zhiqiang& Xu, Bin& Yu, Zhiyi& He, Qin& Hu, Zhuyuan& Zhou, Shishi…[et al.]. Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132547