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Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway
Joint Authors
Xia, Li
Zhou, Yuyan
Yao, Weiqiang
Han, Jun
Wang, Guodong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Triptolide (TP) is the most effective ingredient found in the traditional Chinese herbal Tripterygium wilfordii Hook F, and it is widely used in therapies of autoimmune and inflammatory disorders.
However, the hepatotoxicity induced by TP has restricted its use in clinical trials.
Arctiin is known as a protective agent against oxidative stress, and it exerts liver-protecting effect.
This study was aimed at investigating the protective role of arctiin against TP-induced hepatotoxicity using in vitro and in vivo models.
The results indicated that TP not only obviously induced liver injury in mice but also significantly inhibited the growth of HepG2 cells and increased the level of intracellular reactive oxygen.
Furthermore, TP obviously decreased the expressions of proteins of Nrf2 pathway including HO-1, NQO1, and Nrf2 associated with oxidative stress pathway.
However, the above experimental indexes were reversed by the treatment of arctiin.
Our results suggested that arctiin could alleviate TP-induced hepatotoxicity, and the molecular mechanism is likely related to its capacity against oxidative stress.
American Psychological Association (APA)
Zhou, Yuyan& Xia, Li& Yao, Weiqiang& Han, Jun& Wang, Guodong. 2020. Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132555
Modern Language Association (MLA)
Zhou, Yuyan…[et al.]. Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132555
American Medical Association (AMA)
Zhou, Yuyan& Xia, Li& Yao, Weiqiang& Han, Jun& Wang, Guodong. Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132555