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Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals
Joint Authors
Ullah, Farman
Rehman, Zia Ur
Talpur, Hira Sajjad
Khan, Momen
Hosseini, Seyed Mahdi
Yang, Li Guo
Liang, Aixin
Hua, Guohua
Salim, Mohammad
Ahmad, Saeed
Abulaiti, Adili
Safdar, Muhammad
Kakar, Ihsan Ullah
Ahmad, Zahoor
Ahmad, Muhammad Zulfiqar
Tingzhu, Ye
Schreurs, Nicola M.
Bano, Iqra
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) gene is of the serine/threonine-protein kinase family and influences the production of milk fats and cholesterol by acting on the sterol administrative area restricting protein (SREBP).
The AKT3 gene is highly preserved in animals, and during lactation in cattle, its expression increases.
The AKT3 gene is expressed in the digestive system, mammary gland, and immune cells.
A phylogenetic investigation was performed to clarify the evolutionary role of AKT3, by maximum probability.
The AKT3 gene sequence data of various mammalian species was evident even with animals undergoing breeding selection.
From 39 mammalian species studied, there was a signal of positive diversifying selection with Hominidae at 13Q, 16G, 23R, 24P, 121P, 294K, 327V, 376L, 397K, 445T, and 471F among other codon sites of the AKT3 gene.
These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.
American Psychological Association (APA)
Ullah, Farman& Hosseini, Seyed Mahdi& Liang, Aixin& Hua, Guohua& Rehman, Zia Ur& Talpur, Hira Sajjad…[et al.]. 2020. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132605
Modern Language Association (MLA)
Ullah, Farman…[et al.]. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1132605
American Medical Association (AMA)
Ullah, Farman& Hosseini, Seyed Mahdi& Liang, Aixin& Hua, Guohua& Rehman, Zia Ur& Talpur, Hira Sajjad…[et al.]. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132605