Short-Term Cigarette Smoking in Rats Impairs Physical Capacity and Induces Cardiac Remodeling
Joint Authors
Serra, Andrey Jorge
Bocalini, Danilo Sales
da Silva Luiz, Rafael
Silva, Kleiton Augusto Santos
Avila, Renata Andrade
da Cunha, Márcia Regina Holanda
Tucci, Paulo Jose F.
Leopoldo, André Soares
dos Santos, Leonardo
Lima-Leopoldo, Ana Paula
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite the strong evidence on the cardiac and renal damages after chronic exposure to cigarette smoke, there is a paucity of data on its short-term effects.
The study evaluated the short-term effects of cigarette smoking on left ventricular (LV) remodeling, in vitro myocardial and renal function.
Female Wistar rats were randomized to control (C) and cigarette smoking rats for eight weeks.
Physical capacity was assessed using an adapted model of exhaustive swim; left ventricle (LV) morphology and function were also evaluated.
Renal function was assessed by creatinine clearance and urine protein.
The in vitro myocardial performance was analyzed in isolated papillary muscles.
Rats exhibited reduced physical capacity after short-term cigarette smoking.
Although there was no change on LV function, reduced chamber diameter was found in the smoking group associated with an increased LV wall thickness.
There was augmented cardiac mass compared to C that was confirmed by increased cardiomyocyte nucleus volume, but in vitro myocardial performance and renal function were unchanged.
A short-term cigarette smoking induces cardiac remodeling without abnormalities in function.
The smoking group still preserved renal function and in vitro myocardial performance.
However, the reduced physical capacity may suggest an impairment of the cardiac reserve.
American Psychological Association (APA)
Bocalini, Danilo Sales& da Silva Luiz, Rafael& Silva, Kleiton Augusto Santos& Serra, Andrey Jorge& Avila, Renata Andrade& Leopoldo, André Soares…[et al.]. 2020. Short-Term Cigarette Smoking in Rats Impairs Physical Capacity and Induces Cardiac Remodeling. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132613
Modern Language Association (MLA)
Bocalini, Danilo Sales…[et al.]. Short-Term Cigarette Smoking in Rats Impairs Physical Capacity and Induces Cardiac Remodeling. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132613
American Medical Association (AMA)
Bocalini, Danilo Sales& da Silva Luiz, Rafael& Silva, Kleiton Augusto Santos& Serra, Andrey Jorge& Avila, Renata Andrade& Leopoldo, André Soares…[et al.]. Short-Term Cigarette Smoking in Rats Impairs Physical Capacity and Induces Cardiac Remodeling. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132613