The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts TregTh17 Cell Balance through Interleukin 6
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of this study was to explore the effect of adenosine A2A receptor agonists on fracture healing and the regulation of the immunity system after bone fracture.
We implanted fibrin gel containing adenosine A2A receptor agonist CGS 21680/inhibitor ZM 241385/saline locally in rat tibial fracture models, finding that the adenosine A2A receptor agonist could promote fracture healing.
At the same time, the adenosine A2A receptor agonist decreased the level of IL-6 in blood and the fracture area, increased Treg cells, and decreased Th17 cells in blood of bone fracture rats.
Further, tibial fracture rats implanted with the adenosine A2A receptor agonist gel were injected with IL-6.
We found that IL-6 could reverse the effect of adenosine A2A receptor agonists on fracture healing and Treg/Th17 cells in blood.
Through the above results, we believe that the adenosine A2A receptor agonist can promote fracture healing and regulate Treg/Th17 cells in blood of rats with fractures.
These effects are related to IL-6.
American Psychological Association (APA)
Zheng, Xi& Wang, Dong. 2020. The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts TregTh17 Cell Balance through Interleukin 6. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132619
Modern Language Association (MLA)
Zheng, Xi& Wang, Dong. The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts TregTh17 Cell Balance through Interleukin 6. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1132619
American Medical Association (AMA)
Zheng, Xi& Wang, Dong. The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts TregTh17 Cell Balance through Interleukin 6. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132619