Identification and Analysis of Novel Biomarkers Involved in Chromophobe Renal Cell Carcinoma by Integrated Bioinformatics Analyses
Joint Authors
Zhang, Wei
Xu, Yin
Zhang, Jinghan
Wu, Jun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In renal cell carcinoma, chromophobe renal cell carcinoma (ChRCC) is a distinct subtype, whose clinical manifestations often lack specificity, and the molecular mechanisms of ChRCC tumorigenesis remain generally vague.
The target of this study was to discover novel biomarkers involved in ChRCC by integrated bioinformatics analyses.
We found 2608 differentially expressed genes (DEGs), of which 1518 were upregulated and 1090 were downregulated.
Gene ontology (GO) analysis of DEGs uncovered significant functional enrichment in three aspects: biological process (BP), molecular function (MF), and cellular component (CC).
The results of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated DEGs were largely enriched in retinol metabolism, arachidonic acid metabolism, and pentose and glucuronate interconversions.
Then, the protein–protein interactions (PPI) network was constructed and top three hub genes were identified by the Cytoscape plugin cytoHubba.
Through calculating the degree, betweenness centrality, and Stress of mRNAs, CENPA was upregulated and KNG1 and AGT were downregulated.
A survival assay performed according to Oncomine data showed only CENPA high expression exhibited a worse prognosis.
This study identified crucial genes and pathways for the progress of ChRCC, and CENPA might be a novel biomarker for diagnosis, treatment, and prognosis of ChRCC.
American Psychological Association (APA)
Zhang, Wei& Xu, Yin& Zhang, Jinghan& Wu, Jun. 2020. Identification and Analysis of Novel Biomarkers Involved in Chromophobe Renal Cell Carcinoma by Integrated Bioinformatics Analyses. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132656
Modern Language Association (MLA)
Zhang, Wei…[et al.]. Identification and Analysis of Novel Biomarkers Involved in Chromophobe Renal Cell Carcinoma by Integrated Bioinformatics Analyses. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132656
American Medical Association (AMA)
Zhang, Wei& Xu, Yin& Zhang, Jinghan& Wu, Jun. Identification and Analysis of Novel Biomarkers Involved in Chromophobe Renal Cell Carcinoma by Integrated Bioinformatics Analyses. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132656