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Flavonoids in Ageratum conyzoides L. Exert Potent Antitumor Effects on Human Cervical Adenocarcinoma HeLa Cells In Vitro and In Vivo
Joint Authors
Shen, Jin-Xing
Hou, Youming
Lin, Zeyan
Lin, Yanyan
Jiang, Meijiao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Ageratum conyzoides L.
(A.
conyzoides) is commonly used as a traditional medicine, and its antitumor effects have also been studied.
However, the functional roles of flavonoids in A.
conyzoides in antitumor activities have not been clarified.
The present study is aimed at investigating the biological effects of flavonoids in A.
conyzoides on human cervical adenocarcinoma.
Firstly, we detected that flavonoids in A.
conyzoides significantly inhibited the proliferation, invasion, migration, and clonality of human cervical adenocarcinoma HeLa cells in vitro.
Furthermore, we found that flavonoids in A.
conyzoides induced significant S phase arrest and apoptosis and obviously decreased the intracellular reactive oxygen species (ROS) level in HeLa cells.
Finally, we found that flavonoids in A.
conyzoides significantly inhibited the HeLa xenograft tumor growth and epithelial-mesenchymal transition (EMT) in vivo.
In conclusion, our results demonstrated the obvious antitumor effects of flavonoids in A.
conyzoides on HeLa cells, suggesting that flavonoids in A.
conyzoides could be provided as a novel therapeutic compound for human cervical adenocarcinoma.
American Psychological Association (APA)
Lin, Zeyan& Lin, Yanyan& Shen, Jin-Xing& Jiang, Meijiao& Hou, Youming. 2020. Flavonoids in Ageratum conyzoides L. Exert Potent Antitumor Effects on Human Cervical Adenocarcinoma HeLa Cells In Vitro and In Vivo. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132669
Modern Language Association (MLA)
Lin, Zeyan…[et al.]. Flavonoids in Ageratum conyzoides L. Exert Potent Antitumor Effects on Human Cervical Adenocarcinoma HeLa Cells In Vitro and In Vivo. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132669
American Medical Association (AMA)
Lin, Zeyan& Lin, Yanyan& Shen, Jin-Xing& Jiang, Meijiao& Hou, Youming. Flavonoids in Ageratum conyzoides L. Exert Potent Antitumor Effects on Human Cervical Adenocarcinoma HeLa Cells In Vitro and In Vivo. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132669