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Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637STAT3 Axis in Osteosarcoma
Joint Authors
Xu, Jun
Huang, Zhongyue
Cheng, Xiangyang
Gu, Huijie
Yin, Xiaofan
Yuan, Chunyan
Zhou, Kaifeng
Xia, Jiangni
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent studies have suggested that circular RNAs play an important role in the progression of various cancers.
However, few studies have revealed the great value of circRNAs in the diagnosis and prognosis prediction of osteosarcoma (OS).
In this study, we performed experiments with the human OS cell lines and the results showed that the expression of circHIPK3 in OS cell lines was significantly upregulated compared to that in the normal cell line.
In addition, the results showed that circHIPK3 could promote the migration, invasion, and growth of OS cells.
Furthermore, miR-637 was identified as a target of circHIPK3, while STAT3 was targeted by miR-637.
circHIPK3 could promote STAT3 expression via interacting with miR-637 in OS cells.
In conclusion, our research uncovered an important role of the circHIPK3/miR-637/STAT3 pathway in the migration and invasion of OS cells and suggested that circHIPK3 may be a prognostic marker and a promising therapeutic target for OS.
American Psychological Association (APA)
Huang, Zhongyue& Yuan, Chunyan& Gu, Huijie& Cheng, Xiangyang& Zhou, Kaifeng& Xu, Jun…[et al.]. 2020. Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637STAT3 Axis in Osteosarcoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132692
Modern Language Association (MLA)
Huang, Zhongyue…[et al.]. Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637STAT3 Axis in Osteosarcoma. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132692
American Medical Association (AMA)
Huang, Zhongyue& Yuan, Chunyan& Gu, Huijie& Cheng, Xiangyang& Zhou, Kaifeng& Xu, Jun…[et al.]. Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637STAT3 Axis in Osteosarcoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132692