Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation and Migration of Lung Cancer Cells through Targeting β-CateninAXIN and Presents Synergistic Effect with Cisplatin Suppressing Lung Cancer
Joint Authors
Li, Bo
Zhang, Wei
Tan, Tao
Liu, Wei
Luo, Xian
Zhang, Jun
Yang, Yi
Li, Ruogu
Ge, Zhengxing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Lung cancer is one of the major causes of cancer deaths worldwide, and the five-year survival still remains low despite the improvement of screening, prevention, and treatment methods.
Chinese herbal medicines have been widely used for tumor prevention and treatment.
Miao-Yi-Ai-Tang (Miao) is a novel herbal formulation and shows a potential anticancer effect.
Materials and Methods.
Human Small Cell Lung Cancer Cell was used for study in vitro.
After treatments by Miao and Cisplatin (DDP), the invasion, migration, proliferation, and apoptosis of cells were detected by transwell, wound healing, CCK-8, and flow cytometry, respectively.
The expression of β-catenin, AXIN, and c-myc was detected by qRT-PCR and immunohistochemistry staining.
Western blotting was applied for measuring the protein expression of β-catenin.
Subcutaneously transplanted tumor model of lung cancer NCI-H446 was established to investigate the influence of Miao on tumor growth.
Results.
We found that Miao could inhibit invasion, migration, and proliferation and promote apoptosis of human lung cancer cells.
Meanwhile, Miao and DDP presented synergy regulating the proliferation and apoptosis of lung cancer cells.
The percentage of lung cancer cells in S and G2 stages was increased markedly by Miao.
Besides, the expression of c-myc, AXIN, and β-catenin was markedly inhibited by Miao.
Tumor growth in vivo was markedly inhibited by Miao.
Conclusions.
Chinese herbal formulas Miao could suppress lung cancer through targeting the β-catenin/AXIN signaling pathway.
Therefore, our findings may provide a novel strategy for the prevention and treatment of lung cancer.
American Psychological Association (APA)
Li, Bo& Zhang, Wei& Tan, Tao& Liu, Wei& Luo, Xian& Zhang, Jun…[et al.]. 2020. Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation and Migration of Lung Cancer Cells through Targeting β-CateninAXIN and Presents Synergistic Effect with Cisplatin Suppressing Lung Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132714
Modern Language Association (MLA)
Li, Bo…[et al.]. Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation and Migration of Lung Cancer Cells through Targeting β-CateninAXIN and Presents Synergistic Effect with Cisplatin Suppressing Lung Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1132714
American Medical Association (AMA)
Li, Bo& Zhang, Wei& Tan, Tao& Liu, Wei& Luo, Xian& Zhang, Jun…[et al.]. Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation and Migration of Lung Cancer Cells through Targeting β-CateninAXIN and Presents Synergistic Effect with Cisplatin Suppressing Lung Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132714