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miR-19 Is a Potential Clinical Biomarker for Gastrointestinal Malignancy: A Systematic Review and Meta-analysis
Joint Authors
Song, Xiaoxu
Li, Wenyi
Shen, Peng
Bai, Bing
Cao, Lin-Lin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objectives.
To assess the expression and clinical value of miR-19 in gastrointestinal malignancy.
Setting.
Embase, Web of Science, PubMed, and other databases were retrieved to screen out relevant studies until December 31, 2019.
Participants.
Gastrointestinal cancer patients with the description of miR-19 expression, as well as the correlation between miR-19 and clinicopathological characteristics or prognosis.
Main Outcome Measures.
Pooled odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI) was obtained to determine miR-19 expression in gastrointestinal malignancy and the association between miR-19 and patients’ clinical characteristics and survival.
Results.
Thirty-seven studies were included in this study.
miR-19 levels in gastrointestinal malignancy, especially in hepatocellular (OR=4.88, 95% CI=2.38‐9.99), colorectal (OR=4.81, 95% CI=2.38‐9.72), and pancreatic (OR=5.12, 95% CI=2.43‐10.78) cancers, were significantly overexpressed, and miR-19 was tightly related to some clinicopathological characteristics, such as lymph node metastasis (OR=1.74, 95% CI=1.05‐2.86).
Although gastrointestinal cancer patients with low and high miR-19 expression had comparable OS (overall survival) and DFS (disease-free survival), subgroup analyses showed that patients with high miR-19 presented better DFS than those with low miR-19 in liver cancer (HR=0.46, 95% CI=0.30‐0.71).
Conclusions.
miR-19 might be a potential progression and prognostic biomarker for gastrointestinal malignancy.
American Psychological Association (APA)
Song, Xiaoxu& Li, Wenyi& Shen, Peng& Bai, Bing& Cao, Lin-Lin. 2020. miR-19 Is a Potential Clinical Biomarker for Gastrointestinal Malignancy: A Systematic Review and Meta-analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132731
Modern Language Association (MLA)
Song, Xiaoxu…[et al.]. miR-19 Is a Potential Clinical Biomarker for Gastrointestinal Malignancy: A Systematic Review and Meta-analysis. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1132731
American Medical Association (AMA)
Song, Xiaoxu& Li, Wenyi& Shen, Peng& Bai, Bing& Cao, Lin-Lin. miR-19 Is a Potential Clinical Biomarker for Gastrointestinal Malignancy: A Systematic Review and Meta-analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1132731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132731