Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells
Joint Authors
Gonçalves-de-Albuquerque, C. F.
Burth, P.
Souza-Souza, Kauê F. C.
Cirne-Santos, Cláudio
Paixão, Izabel C. N. P.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alphaviruses are arthropod-borne viruses that can cause fever, rash, arthralgias, and encephalitis.
The mosquito species Aedes aegypti and Aedes albopictus are the most frequent transmitters of alphaviruses.
There are no effective vaccines or specific antivirals available for the treatment of alphavirus-related infections.
Interestingly, changes in ion concentration in host cells have been characterized as critical regulators of the alphavirus life cycle, including fusion with the host cell, glycoprotein trafficking, genome translation, and viral budding.
Cardiac glycosides, which are classical inhibitors of the Na+ K+ ATPase (NKA), can inhibit alphavirus replication although their mechanisms of action are poorly understood.
Nonetheless, results from multiple studies suggest that inhibition of NKA may be a suitable strategy for the development of alphavirus-specific antiviral treatments.
This review is aimed at exploring the role of changes in ion concentration during alphavirus replication and at considering the possibility of NKA as a potential therapeutic target for antiviral drugs.
American Psychological Association (APA)
Souza-Souza, Kauê F. C.& Gonçalves-de-Albuquerque, C. F.& Cirne-Santos, Cláudio& Paixão, Izabel C. N. P.& Burth, P.. 2020. Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132735
Modern Language Association (MLA)
Souza-Souza, Kauê F. C.…[et al.]. Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132735
American Medical Association (AMA)
Souza-Souza, Kauê F. C.& Gonçalves-de-Albuquerque, C. F.& Cirne-Santos, Cláudio& Paixão, Izabel C. N. P.& Burth, P.. Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132735