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Characterization of Plasmid-Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients
Joint Authors
Sadeghi, Amin
Halaji, Mehrdad
Fayyazi, Amirhossein
Havaei, Seyed Asghar
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Urinary tract infection (UTI) is one of the most frequent infections in kidney transplant patients (KTPs).
This infection is mainly caused by uropathogenic Escherichia coli (UPEC).
Plasmid-mediated quinolone resistance (PMQR) was also increasingly identified in UPEC.
This study proposed to investigate the frequency of quinolone-resistance plasmid genes and the O-antigen serogroup among UPEC isolated from KTPs and non-KTP with UTI.
Methods.
Totally, 114 UPEC isolates from 49 KTPs and 65 non-KTPs patients diagnosed with an UPEC-associated UTI were obtained from June 2019 to December 2019 at three laboratory centers in Isfahan, Iran.
The isolates were confirmed through phenotypic and genotypic methods.
Moreover, the antimicrobial susceptibility test to nalidixic acid, ciprofloxacin, norfloxacin, and ofloxacin was performed using a disk diffusion method.
The presence of the qnr gene as well as the serogroup distribution was identified using the PCR method.
Result.
According to data, the distribution of O1, O2, O4, O16, and O25 serogroups were 3.5%, 2.6, 3.5, 3.5, and 20.2%, respectively.
Antibiotic susceptibility pattern revealed that the highest and lowest resistance rates were to nalidixic acid (69.3%) and norfloxacin (43.9%), respectively.
Also, the frequency of qnrS and qnrB genes were 33.3% and 15.8%, respectively, while none of the isolates was found to be positive for the qnrA gene.
There was no significant association between the presence of qnr genes and higher antibiotic resistance.
Conclusion.
This study recognized that the qnrS gene, O25 serotype, and resistance to nalidixic acid had the highest frequencies in UPEC strains isolated from UTI patients.
American Psychological Association (APA)
Sadeghi, Amin& Halaji, Mehrdad& Fayyazi, Amirhossein& Havaei, Seyed Asghar. 2020. Characterization of Plasmid-Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132754
Modern Language Association (MLA)
Sadeghi, Amin…[et al.]. Characterization of Plasmid-Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132754
American Medical Association (AMA)
Sadeghi, Amin& Halaji, Mehrdad& Fayyazi, Amirhossein& Havaei, Seyed Asghar. Characterization of Plasmid-Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132754