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Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction
Joint Authors
Ma, Qing
Xu, Yao
Tang, Lumin
Yang, Xiaoqian
Chen, Zhejun
Wei, Yuehan
Shao, Xinghua
Shao, Xiaoguang
Xin, Zhixiang
Cai, Biao
Wang, Qi
Mou, Shan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cisplatin is a widely used chemotherapeutic drug in the treatment of various solid tumors.
However, the cisplatin-induced acute kidney injury remains a disturbing complication, which still lacks effective prevention.
Cisplatin-induced oxidative damage and mitochondrial dysfunction are anticipated to be crucial in the occurrence of kidney injury.
Astragalus polysaccharide (APS) has been reported to possess multiple biological activities including anti-inflammatory, antioxidant, and mitochondria protection.
In this study, we investigated the potentially protective effect of APS against cisplatin-induced kidney injury both in vivo and in vitro.
We found that APS pretreatment attenuated the cisplatin-induced renal dysfunction and histopathological damage in mice; in addition, it also protected the viability of HK-2 cells upon cisplatin exposure.
APS attenuated the cisplatin-induced oxidative damage by reducing reactive oxygen species (ROS) generation and recovering the activities of total superoxide dismutase and glutathione peroxidase in mice kidney.
In addition, electron microscope analysis indicated that cisplatin induced extensive mitochondrial vacuolization in mice kidney.
However, APS administration reversed these mitochondrial morphology changes.
In HK-2 cells, APS reduced the cisplatin-induced mitochondrial and intracellular ROS generation.
Furthermore, APS protected the normal morphology of mitochondria, blocked the cisplatin-induced mitochondrial permeability transition pore opening, and reduced the cytochrome c leakage.
Subsequently, APS reduced the cisplatin-induced apoptosis in mice renal and HK-2 cells.
In conclusion, our data suggested that APS pretreatment might prevent cisplatin-induced kidney injury through attenuating oxidative damage, protecting mitochondria, and ameliorating mitochondrial-mediated apoptosis.
American Psychological Association (APA)
Ma, Qing& Xu, Yao& Tang, Lumin& Yang, Xiaoqian& Chen, Zhejun& Wei, Yuehan…[et al.]. 2020. Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132759
Modern Language Association (MLA)
Ma, Qing…[et al.]. Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132759
American Medical Association (AMA)
Ma, Qing& Xu, Yao& Tang, Lumin& Yang, Xiaoqian& Chen, Zhejun& Wei, Yuehan…[et al.]. Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132759