The Development and Application of a Base Editor in Biomedicine
Joint Authors
Wang, Fang
Zeng, Yuqiang
Wang, Yi
Niu, Yuyu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Using a base editor to generate monogenic disease models and correct pathogenic point mutations is a breakthrough technology for exploration and treatment of human diseases.
As a burgeoning approach for genomic modification, the fused CRISPR/Cas9 with various deaminase separately has significantly increased the efficiency of producing a precise point mutation with minimal insertions or deletions (indels).
Along with the flexibility and efficiency, a base editor has been widely used in many fields.
This review discusses the recent development of a base editor, including evolution and advance, and highlights the applications and challenges in the field of gene therapy.
Depending on rapid improvement and optimization of gene editing technology, the prospect of base editor is immeasurable.
American Psychological Association (APA)
Wang, Fang& Zeng, Yuqiang& Wang, Yi& Niu, Yuyu. 2020. The Development and Application of a Base Editor in Biomedicine. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132800
Modern Language Association (MLA)
Wang, Fang…[et al.]. The Development and Application of a Base Editor in Biomedicine. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132800
American Medical Association (AMA)
Wang, Fang& Zeng, Yuqiang& Wang, Yi& Niu, Yuyu. The Development and Application of a Base Editor in Biomedicine. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132800